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Download Autophagy Networks in Inflammation by Maria Chiara Maiuri, Daniela De Stefano PDF

By Maria Chiara Maiuri, Daniela De Stefano

Autophagy mostly serves an adaptive functionality to guard organisms opposed to various human pathologies, together with melanoma and neurodegeneration. contemporary advancements utilizing in vitro, ex vivo and in vivo versions exhibit the involvement of the autophagy pathway in immunity and irritation. in addition, direct interactions among autophagy proteins and immune signalling molecules have additionally been verified. Defects in autophagy - just like melanoma, neurodegenerative illnesses and getting older - via autophagy gene mutation and/or microbial antagonism, might underlie the pathogenesis of many infectious illnesses and inflammatory syndromes. inspite of the expanding understanding of the significance of autophagy in those pathophysiological stipulations, this procedure is still underestimated and is usually missed. to that end, its function within the initiation, balance, upkeep, and development of those ailments are nonetheless poorly understood. This e-book stories the hot advances concerning the features of the autophagy pathway and autophagy proteins in immunity and irritation, targeting their position in self-nonself contrast, their implications in innate and adaptive immune responses and their dysregulation within the pathology of convinced inflammatory and autoimmune diseases.

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Example text

Unlike rearranged antigen receptors of the adaptive immune system whose specificity is not predefined, innate immunity receptors are germline-encoded receptors that do not require gene rearrangement processes and are distributed in a non-clonal manner. Rather than particular molecules, they have evolved to primarily recognize invariant molecular patterns that are shared by large groups of microorganisms and are unlikely to vary without deleterious consequences for the persistence of microbes themselves, thus limiting the possibility that microbial mutations promotes escape from innate immunity recognition [44, 68].

Thus, the M45 factor of the murine cytomegalovirus interacts with a NF-κB regulatory factor called NEMO causing its degradation by autophagy and alteration of NF-κB-related antiviral genes induction [29]. In dendritic cells, HIV-1 inhibits autophagy rapidly after infection via its viral envelope protein. This inhibition interferes with innate immune response such as TLRs-induced TNF-α production [7]. A similar inhibition has been observed in the case of HCMV. While HCMV promotes the autophagic flux early after infection, it blocks autophagosome maturation at latter time points via de novo synthesis of the TRS1 viral factor, which interacts with Beclin-1.

In the recent years, it was found that CD46 crosslinking indeed induces autophagosome formation in an ATG5/ATG7-dependent fashion. This induction involved the scaffold protein GOPC that interacts with the Cyt-1 isoform of CD46 on one hand and with the Beclin-1/VPS34 complex on the other hand [46]. Autophagy induction also occurs upon recognition of Edmonston measles virus and emm6+ group A Streptococcus. Group A Streptococcus substrains unable to bind CD46 were slowly degraded relative to emm6+ substrains.

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