By William W. Cohen
This useful advisor offers a succinct therapy of the overall techniques of cellphone biology, furnishing the pc scientist with the instruments essential to learn and comprehend present literature within the field.
The e-book explores 3 varied aspects of biology: biological structures, experimental methods, and language and nomenclature. After a quick advent to telephone biology, the textual content specializes in the rules at the back of the most-widely used experimental techniques and mechanisms, referring to them to well-understood innovations in machine technology.
The presentation of the cloth has been ready for the reader’s quickly take hold of of the subject: reviews on nomenclature and heritage notes might be ascertained at a look, and crucial vocabulary is boldfaced through the textual content for simple identification.
Computer technological know-how researchers, execs and desktop technological know-how scholars will locate this an incomparable source and a very good start line for a extra accomplished exam of telephone biology.
"This concise ebook is a superb advent for laptop scientists to the interesting revolution less than means in molecular biology. It presents lucid, high-level descriptions of the elemental molecular mechanisms of lifestyles, and discusses the computational rules concerned. I want this little gem used to be to be had whilst i used to be ‘learning the ropes’– it can were my first collection of interpreting material."
--Roni Rosenfeld, Carnegie Mellon University
Read or Download A Computer Scientist's Guide to Cell Biology: A travelogue from a stranger in a strange land PDF
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Additional info for A Computer Scientist's Guide to Cell Biology: A travelogue from a stranger in a strange land
Separating and sorting the fragments of the protein, using a gel or chromatography, will produce a specific pattern called a peptide map. Assuming that the “sorting” is done according to some function f(z), where z is a fragment, one could formally represent the peptide map for protein P as a function hP(n), in which hP(n) is the number of fragments z in P such that f(z)=n. The peptide map is a “fingerprint” for the protein, and can be used to identify it from a list of candidates that have been previously “fingerprinted” by the same procedure.
Edu/ William W. Cohen 55 prefer to view this from a programming prospective, and think of resources (like GFP-tagged yeast) as a sort of “subroutine package” for biological experiments. In programming, one might save time by using some other hacker’s machine-learning software package; in biology, one might save time by using some other biologists’ library of genetically engineered yeast. Classifying small things by taking them apart Let us now return to our discussion of experimental methods in biology.
The base complementary to adenine is thymine, abbreviated “T,” and hence most mRNA will easily hybridize to a nucleic acid that consists of a long sequence of thymine residues. This means that one can easily use affinity chromatography to purify mRNA from a whole cell extract. A microarray is an array of thousands Both DNA and RNA can be of locations, each of which contains either single-stranded, or DNA for a different gene. Thanks to the double-stranded. In double magic of gene sequencing, VLSI-scale stranded DNA/RNA, each is complementary to engineering, and robotics, a microarray strand the other.